Effectiveness of manual therapy with and without exercise in chronic ankle instability for pain, mobility, and function: a systematic review and meta-analysis

Key Points

• This review aims to evaluate the effectiveness of manual therapy, both with and without exercise, on pain, mobility, and function in chronic ankle instability.
• Conducted a systematic review and meta-analysis of existing studies
• Included studies that assessed manual therapy for chronic ankle instability
• Analyzed outcomes related to pain, mobility, and self-perceived function
• Evaluated data against minimally clinically important difference (MCID) values
• Manual therapy showed effectiveness for improving ankle range of motion
• Participants reported improvement in self-perceived function, as measured by CAIT
• Effectiveness below MCID values indicates limited clinical significance
• Overall certainty of evidence was assessed as low