Design and assessment of dimeric trehalose glycolipids as a strategy to enhance Mincle-mediated vaccine adjuvanticity

Key Points

• The aim is to evaluate the effectiveness of dimeric trehalose glycolipids in enhancing Mincle-mediated immune responses.
• Synthesis of dimeric trehalose glycolipids
• In vitro evaluation of Mincle clustering
• Assessment of immune response metrics in vitro
• Dimeric glycolipids effectively cluster Mincle receptors
• Enhanced immune activation compared to monomeric counterparts
• Increased production of cytokines indicative of improved adjuvanticity