124 I-radiolabeled Exosome-Based Treatment Platform for Enhanced Boron Neutron Capture Therapy: Precise Delivery and Real-Time PET Tracking of Boron

Key Points

• The aim is to develop an exosome-based platform for the targeted delivery of boron in BNCT, improving treatment precision.
• Developed a radiolabeled exosome-based system for boron delivery.
• Utilized positron emission tomography (PET) for real-time tracking of boron distribution in tumors.
• Conducted evaluations of boron accumulation and its effects during neutron irradiation.
• The exosome platform showed significantly increased boron accumulation in tumor cells compared to traditional methods.
• Real-time PET tracking allowed for precise monitoring of boron distribution during therapy.
• The treatment enhanced the effectiveness of BNCT by ensuring better synchronization with neutron irradiation.