K + /Cu 2+ Co-chelated diastereoselective Friedel–Crafts reaction with chiral N -sulfinyl ketimines for the facile synthesis of chiral bisindoles and their cytotoxicity | Synapse
February 6, 2026RSC Advances0 citationsOpen Access
K + /Cu 2+ Co-chelated diastereoselective Friedel–Crafts reaction with chiral N -sulfinyl ketimines for the facile synthesis of chiral bisindoles and their cytotoxicity
The aim is to develop a new method for synthesizing chiral bisindoles using a diastereoselective Friedel–Crafts reaction.
Developed a K+/Cu2+ co-chelation strategy
Utilized chiral N-sulfinyl ketimines as substrates
Conducted diastereoselective reactions to synthesize chiral products
Successful synthesis of chiral bisindoles was achieved
Demonstrated improved diastereoselectivity compared to previous methods
Abstract
A novel K + /Cu 2+ co-chelated diastereoselective Friedel–Crafts reaction with chiral N -sulfinyl ketimines has been developed for the synthesis of chiral bisindoles.