The study aims to visualize g-quadruplex DNA structures in cells using platinum-based phosphorescent probes.
Developed platinum-based phosphorescent lifetime probes.
Applied probes to cellular models to detect g-quadruplex DNA.
Utilized imaging techniques to visualize the probes in live cells.
Successfully visualized g-quadruplex DNA structures in cellular environments.
Probes showed distinct lifetime characteristics when bound to g-quadruplexes.
Demonstrated the biological relevance of g-quadruplex structures in cellular regulation.
Abstract
DNA can fold into a range of different structures besides the canonical double helix. These structures have been shown to play important biological regulatory roles, highlighting that is not only...