A randomised, placebo-controlled trial in healthy humans of modified cellulose or psyllium evaluating the role of gelation in altering colonic gas production during inulin co-administration

Key Points

• The study aims to assess how gel-forming, poorly fermented fibres influence colonic gas production when combined with rapidly fermentable fibres like inulin.
• Randomised and placebo-controlled trial design
• Involves healthy human participants
• Comparison of modified cellulose and psyllium
• Measurement of colonic gas production
• Co-administration of inulin with test fibres
• Gel-forming fibres significantly altered colonic gas production compared to placebo
• Psyllium showed a different gas production profile than modified cellulose
• Both fibres impacted gas symptoms, indicating dietary choices can influence digestive comfort