Incident cardiovascular disease was associated with a 49% increased risk of malignant brain tumors compared to no cardiovascular disease (HR 1.49; 95% CI 1.37-1.62).
Cohort (n=8,318,580)
Yes
Does incident cardiovascular disease increase the risk of malignant brain tumors in adults?
Incident cardiovascular events, particularly atrial fibrillation and stroke, are associated with a significantly increased risk of subsequent malignant brain tumors.
Effect estimate: HR 1.49 (95% CI 1.37-1.62)
Abstract Introduction Previous studies have shown that patients with diagnosis of cardiovascular disease (CVD) have an increased risk of cancer as compared to those without history of CVD (1,2). However, this association has not been extensively studied for detailed subtypes of CVD and malignant brain tumor in a large, population-based cohort. Objective To investigate the association between incident CVD and malignant brain tumor by detailed CVD subtypes in a nationwide cohort of adults. Methods Using the National Health Insurance Service (NHIS) claims database over 9 million individuals without history of previous CVD, we identified 8,318,580 cancer-free adults 19 years or older with data on incident CVD between January 1, 2013 and December 31, 2015. These individuals were classified based on the occurrence of incident CVD, including atrial fibrillation (AF), heart failure (HF), total stroke (TS), ischaemic stroke (IS), haemorrhagic stroke (HS), and coronary heart disease (CHD). Follow-up began at the date of incident CVD and continued to the date of malignant brain tumors, death, or December 31, 2022, whichever occurred first. We used multivariable-adjusted Cox regression modeling to estimate the risk of malignant brain tumors (gliomas and related, acoustic neuroma, choroid plexus tumors according to CVD and subtypes. Results Among the 8,318,580 individuals, those who experienced CVD accounted for 317,111 cases (3.8%). his group was older, with a mean age of 62.4 years compared to 50.5 years in those without CVD, and included a higher proportion of males, at 50.1% compared to 41.3% in the non-CVD group. Incident CVD was associated with a 49% increased risk of malignant brain tumor (hazard ratio HR, 1.49; 95% confidence intervals CI, 1.37-1.62). The multivariable adjusted HRs and 95% CIs for malignant brain tumor among those with incident CVD subtypes were 1.59 (1.08-2.35) for AF, 1.17 (0.72-1.89) for HF, 1.74 (1.49-2.03) for TS, 1.45 (1.16-1.81) for IS, 2.89 (2.02-4.14) for HS, and 1.09 (0.90-1.33) for CHD as compared to those without CVD, respectively. Conclusion In this nationwide cohort of adults aged 19 years and older, most cardiovascular events, particularly AF and stroke, were associated with an increased risk of malignant brain tumors, while statistical significance was attenuated for certain subtypes such as HF and coronary heart disease.Figure 1
Kim et al. (Sat,) conducted a cohort in Incident cardiovascular disease (n=8,318,580). Incident cardiovascular disease vs. No incident cardiovascular disease was evaluated on Malignant brain tumors (HR 1.49, 95% CI 1.37-1.62). Incident cardiovascular disease was associated with a 49% increased risk of malignant brain tumors compared to no cardiovascular disease (HR 1.49; 95% CI 1.37-1.62).