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February 8, 2026Open Access

Integrated spectral and depth compensation approach for optimizing oxygen saturation and total hemoglobin estimation in photoacoustic tomography for ovarian lesion diagnosis

LWL. WangWashington University in St. Louis YLYixiao LinWashington University in St. Louis HNHaolin NieWashington University in St. Louis

Key Points

To optimize oxygen saturation and total hemoglobin estimation in photoacoustic tomography for detecting ovarian lesions.
Developed an integrated spectral and depth compensation (ISDC) approach.
Applied ISDC to photoacoustic tomography (PAT) systems.
Characterized ovarian lesions using enhanced imaging techniques.
Significant improvement in quantitative accuracy of oxygen saturation estimation.
Better diagnostic performance for identifying ovarian lesions.
Support for future clinical application of ISDC in ultrasound-PAT systems.

Abstract

The ISDC approach significantly enhances the quantitative accuracy and diagnostic performance of PAT by compensating for both spectral and depth fluence variations within biological tissue. These improvements support the integration of ISDC into US-PAT systems for ovarian lesion characterization and future clinical applications.

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