Monocyte distribution width (MDW) is a promising biomarker for early sepsis detection, but its use in Asian populations has been limited due to the lack of region-specific reference intervals (RIs). This study aimed to establish the first MDW RI for healthy Chinese adults using EDTA-K2 anticoagulant, strictly following CLSI EP28-A3C guidelines. A total of 262 samples from healthy Chinese blood donors were analyzed using a Beckman Coulter DxH 900 analyzer. Statistical methods included Shapiro-Wilk tests for normality, t-tests, ANOVA for group differences, and Spearman correlation analysis, with RIs calculated using parametric, non-parametric, and robust methods. The parametric RI limits were determined to be 14.48 (90% CI 14.16-14.80) and 21.56 (90% CI 21.24-21.88), closely aligning with results from the robust method (14.41-21.55) and non-parametric method (14.70-21.52). Our findings are consistent with Spanish data obtained using EDTA-K2 anticoagulant but differ from Italian data that used EDTA-K3, highlighting the potential impact of anticoagulant type on MDW values. This RI is unaffected by gender or age, providing a critical diagnostic tool for early sepsis detection in Chinese clinical practice and emphasizing the need for further studies to investigate anticoagulant influences for global standardization.
Wei et al. (Wed,) studied this question.
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