Pannexin-1 Inhibits Pathologic Neovascularization in Oxygen-Induced Retinopathy by Targeting the HIF-1α/VEGF Pathway in Vitro

Key Points

• This research aims to investigate how Pannexin-1 inhibition affects neovascularization in a model of oxygen-induced retinopathy.
• Used PBC to inhibit Panx1 in vitro.
• Assessed effects on HIF-1α/VEGF signaling pathway.
• Measured hypoxia-induced endothelial cell proliferation.
• HIF-1α/VEGF signaling was significantly suppressed with Panx1 inhibition.
• Endothelial cell proliferation was reduced under hypoxic conditions.