The aim is to explore how glucocorticoids affect gene expression in eye cells, contributing to ocular hypertension.
Analyzed transcriptomic changes in trabecular meshwork and Schlemm's canal cells over time.
Identified candidate genes related to glucocorticoid exposure.
Explored potential pathways involved in ocular hypertension.
Candidate genes linked to glucocorticoid-induced changes were identified.
Pathways related to ocular hypertension were proposed for further genetic studies.
Abstract
This study identified candidate genes and pathways for glucocorticoid-induced ocular hypertension which can be further explored in human genetic analyses.
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Time-Dependent Glucocorticoid-Induced Transcriptomic Changes in Human Trabecular Meshwork and Schlemm's Canal Cells | Synapse