Invasive versus conservative strategy in older adults ≥70 years of age with non-ST-segment–elevation myocardial infarction: a GRADE-assessed systematic review and meta‐analysis of randomized controlled trials with trial sequential analysis

Key Result

An invasive strategy reduced all-cause mortality by 25% compared to conservative management in older adults with non-ST-segment elevation myocardial infarction.

Key Points

• The research aims to compare invasive and conservative treatment strategies for older adults with non-ST-segment elevation myocardial infarction.
• Conducted a systematic review and meta-analysis of randomized controlled trials.
• Included studies with older adults aged 70 years and above.
• Performed trial sequential analysis to evaluate robustness of findings.
• Found differences in health outcomes between invasive and conservative strategies.
• Noted that one strategy may be more effective based on specific patient factors.
• Results suggest varying benefits depending on individual health profiles.