What question did this study set out to answer?

This study aims to evaluate the diagnostic performance of various insulin resistance markers in patients with metabolic dysfunction-associated fatty liver disease (MAFLD).

February 8, 2026Open Access

Comparing the diagnostic performance of metabolic indices in metabolic dysfunction-associated fatty liver disease patients: a retrospective cross-sectional study

Key Points

This study aims to evaluate the diagnostic performance of various insulin resistance markers in patients with metabolic dysfunction-associated fatty liver disease (MAFLD).
Conducted a retrospective cross-sectional study.
Analyzed the associations between insulin resistance markers (TyG, HOMA-IR, eGDR) and MAFLD.
Compared the performance of these markers across different subgroups.
TyG showed the highest predictive performance for MAFLD in most groups.
In males, HSI outperformed TyG for predicting MAFLD.
In individuals under 65 years old, eGDR had better performance than TyG.

Abstract

Insulin resistance markers, including TyG, HOMA-IR, and eGDR, had the strongest associations with MAFLD. For predicting MAFLD, TyG had the highest performance across all subgroups, except for males and those < 65 years, where HSI and eGDR performed better, respectively.

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