Panaxatriol Improves the Disorder of Lipid Metabolism and Intestinal Flora in Rats Fed With a High‐Fat Diet

ABSTRACT The ability of ginsenosides to regulate lipid metabolism in vivo and in vitro has been widely studied; however, the effect of panaxatriol (PT) on reducing blood lipids and its impact on intestinal microflora have not been investigated. The results of this study show that PT can not only significantly reduce the level of ALT but also effectively alleviate fatty degeneration and lipid droplet deposition in hepatocytes, thereby improving the pathological damage to the liver. It can also significantly reduce serum TC, TG, and LDL‐C levels and increase HDL‐C. At the same time, PT can significantly increase SOD activity, decrease MDA content, and inhibit the increase of coagulation factors such as TXB2, thus alleviating vascular endothelial injury. In addition, PT decreased the abundance of intestinal flora, increased the ratio of Firmicutes to Bacteroidetes , increased the abundance of Akkermansia , and decreased the abundance of Prevotella . Our research shows that PT can effectively alleviate the lipid metabolism disorder induced by the high‐fat and high‐sugar diet by improving liver lipid deposition, enhancing antioxidant capacity, regulating blood coagulation function, and reshaping intestinal flora structure, suggesting that PT has potential application value in the treatment of metabolic syndrome.