FUS and TDP-43 aggregation are uncoupled from toxicity in ageing yeast models

Key Points

• The research aims to explore the relationship between FUS and TDP-43 aggregation and toxicity in aging yeast models.
• Utilized yeast models to investigate FUS and TDP-43 behavior.
• Analyzed the effects of aggregation on cell toxicity and longevity.
• Compared outcomes with different concentrations and conditions.
• FUS and TDP-43 aggregation did not correlate with increased toxicity.
• Aggregates were associated with enhanced longevity in yeast.
• The findings suggest protective roles of these aggregates against cellular damage.