miR-326 promotes osteogenic differentiation of bone marrow mesenchymal stem cells by targeting NAT10

Key Points

• To investigate the role of miR-326 in promoting osteogenic differentiation of bone marrow mesenchymal stem cells and its implications for osteoporosis.
• Analyzed miR-326 expression in osteoporosis (OP) samples
• Conducted experiments on human bone marrow mesenchymal stem cells (hBMSCs)
• Examined the effects of miR-326 on osteogenic differentiation and inflammatory responses
• miR-326 is downregulated in OP conditions
• Overexpression of miR-326 enhances osteogenic differentiation in hBMSCs
• miR-326 inhibits inflammatory responses by targeting NAT10