Participants with higher remnant cholesterol (RC) and hs-CRP levels had significantly increased metabolic syndrome risk, especially in females; 34.1% developed Mets over 10 years.
Do elevated remnant cholesterol and hs-CRP levels increase the risk of developing metabolic syndrome in adults aged 35 to 65?
Elevated remnant cholesterol, particularly when combined with high hs-CRP, is a significant predictor for the development of metabolic syndrome over a 10-year period, especially in women.
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Abstract Background Metabolic syndrome (MetS) is a group of related metabolic disorders, such as central obesity, dyslipidemia, hypertension, and hyperglycemia, which together increase the risk of cardiovascular disease, stroke, and type 2 diabetes. The impact of high-sensitivity C-reactive protein (hs-CRP) and remnant cholesterol (RC) on the development of metabolic syndrome is not well understood. Purpose This study investigates the incidence of Mets and its relationship with high-sensitivity hs-CRP and RC levels among participants in a large cohort study. Methods This study, initiated in 2007, conducted an extensive survey of the population using stratified cluster sampling. A total of 9,704 individuals aged 35 to 65 were recruited, with 7,560 completing the decade-long follow-up. This analysis focused on 4,691 participants without Mets at baseline. Demographic, anthropometric, biochemical, and clinical data were meticulously collected. Statistical analyses, including Cox regression, were performed using SPSS version 26 to assess the associations between hs-CRP, RC levels, and the development of Mets. Results Over the decade, 1,599 participants (34.1%) developed Mets. Higher RC levels, particularly when combined with elevated hs-CRP, significantly increased the risk of Mets, with a more pronounced effect in females. Elevated hs-CRP alone did not significantly increase Mets risk(Table 1).Participants with higher RC and hs-CRP levels exhibited greater obesity, higher blood pressure, and adverse lipid profiles, indicating a higher risk of cardiovascular diseases. The shortest median survival times were observed in the RC ≥ 24 & hsCRP ≥ 3 group, with males generally having slightly longer survival times than females.(Table 2) Conclusion Our findings highlight the critical role of RC and hs-CRP levels in predicting Mets and associated health outcomes. Monitoring these biomarkers is essential for early identification and management of at-risk individuals, especially females. Future research should focus on elucidating the underlying mechanisms and developing targeted interventions to mitigate the health risks associated with elevated RC and hs-CRP levels.table 1 table 2
Bikdelu et al. (Sat,) reported a other. Participants with higher remnant cholesterol (RC) and hs-CRP levels had significantly increased metabolic syndrome risk, especially in females; 34.1% developed Mets over 10 years.