What question did this study set out to answer?

The research aims to synthesize derivatives of 2-oxomethylcytisine and evaluate their nootropic activity.

February 8, 2026

Synthesis of 2-Oxomethylcytisine Derivatives with Nootropic Activity

Key Points

The research aims to synthesize derivatives of 2-oxomethylcytisine and evaluate their nootropic activity.
Synthesis of a library of 2-oxomethylcytisine derivatives with various linkers.
In vivo analysis of the synthesized compounds using the CPAR test.
Comparative evaluation against the reference drug Piracetam.
Three synthesized samples exhibited comparable or superior nootropic activity to Piracetam.
The derivatives included various modifications such as aminomethyl and propenone spacers.
Diels–Alder adducts were also part of the synthesized library.

Abstract

A library of 2-oxomethylcytisine derivatives, including conjugates with a phenyl fragment linked to the starting molecule via aminomethyl, acyl, ethenyl, ethyl, thio-, and carboxamide, as well as propenone spacers, has been synthesized. This library also includes Diels–Alder adducts with N-substituted maleinimides. The nootropic activity of the synthesized compounds was studied in vivo using the CPAR test. Three samples were found to have comparable or superior activity to the reference drug Piracetam.

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