Amarogentin relieves cholestatic liver injury caused by ANIT in rats by regulating the FXR and Nrf2 pathways.

Key Points

• The aim is to explore how amarogentin (AG) alleviates cholestatic liver injury induced by ANIT.
• Administered amarogentin to rats with ANIT-induced liver injury.
• Measured bile flow rates and liver function markers.
• Assessed liver histology for structural changes.
• Analyzed the activation of Nrf2 and PI3K/Akt signaling pathways.
• Amarogentin improved bile flow rates significantly.
• Reduced liver function marker levels and serum enzyme concentrations.
• Enhanced histological appearance of the liver.
• Activated Nrf2 signaling through the PI3K/Akt pathway.