After PVC ablation, 61.6% of patients with reduced EF experienced EF recovery, linked to female sex, symptoms, group 1 anti-arrhythmics, and shorter sinus QRS.
What are the clinical characteristics predicting ejection fraction recovery after successful premature ventricular complex ablation?
Following successful PVC ablation, over 60% of patients with reduced EF experience recovery, with specific clinical and electrocardiographic features predicting the likelihood of improvement.
Absolute Event Rate: 0% vs 0%
Abstract Background Premature ventricular complexes (PVCs) are the most common ventricular arrhythmia. Though generally benign, patients with a significant burden can develop a PVC induced cardiomyopathy (PIC) characterized by left ventricular dysfunction and chamber dilatation. In cases refractory to medical therapy, catheter ablation may be performed to eliminate the arrhythmia. The clinical characteristics of those who develop PIC and those who experience cardiac recovery following ablation is incompletely understood. Purpose The aim of this study is to identify potential predictors of PIC and factors influencing recovery. Methods All patients who underwent successful PVC ablation at a single institution since 2000 were identified. Patients were included if there was sufficient data regarding medical and PVC history, echocardiography, and the ablation procedure. We defined reduced ejection fraction (EF) as 50% and "recovery" as either return of EF to 50% or more than 10% increase in EF following ablation. A univariate analysis was performed for each variable collected. Results A total of 226 patients were identified, of whom 153 (67.7%) had preserved EF and 73 (32.3%) had reduced EF. Following ablation, 45 of 73 patients (61.6%) had recovery of EF. Significant differences are noted between these populations. Patients with preserved at time of ablation and those who experience EF recovery following ablation were more likely to be symptomatic, female, prescribed group 1 anti-arrhythmic medication, and have a shorter sinus QRS. Patients who did not experience EF recovery were more likely to have chronic kidney disease, take class 3 anti-arrhythmic medications or digoxin, and have a baseline conduction disorder. Full results are shown in the figure. Conclusion There are significant differences between patients who undergo PVC ablation who have preserved EF, those who experience a recovery of EF, and those who do not have EF recovery.
Fretz et al. (Sat,) reported a other. After PVC ablation, 61.6% of patients with reduced EF experienced EF recovery, linked to female sex, symptoms, group 1 anti-arrhythmics, and shorter sinus QRS.