Lacticaseibacillus rhamnosus DACN152 effectively ameliorated letrozole-induced polycystic ovary syndrome: Sex hormones homeostasis, microbiota and metabolite profiles

Key Points

• To evaluate the effects of Lacticaseibacillus rhamnosus DACN152 on polycystic ovary syndrome in a letrozole-induced murine model.
• Utilized a letrozole-induced PCOS murine model
• Administered Lactobacillus strain DACN152
• Assessed ovarian histopathology and sex hormone levels
• Analyzed microbiota and metabolite profiles
• DACN152 improved ovarian histopathology compared to controls
• Significant alterations in sex hormone levels were observed
• Positive modulation of microbiota and metabolite profiles noted