Clonal hematopoiesis of indeterminate potential (CHIP) showed no significant impact on cardiac remodeling or myocardial strain in atrial fibrillation patients.
Does the presence of clonal hematopoiesis of indeterminate potential (CHIP) affect cardiac remodeling assessed by four-chamber strain in patients with atrial fibrillation?
In patients hospitalized for atrial fibrillation, the presence of clonal hematopoiesis of indeterminate potential (CHIP) was not associated with significant differences in four-chamber cardiac strain.
Absolute Event Rate: 0% vs 0%
Abstract Introduction Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as an unrecognized, potent, age-related risk factor for atherosclerosis and cardiovascular complications. The presence of CHIP may contribute to the risk of atrial fibrillation (AF) and heart failure through its association with inflammation and cardiac remodelling. However, few studies have focused on the impact of clonal hematopoiesis on cardiac remodelling in these conditions. Purpose We hypothesized that patients with AF might have a distinct pattern as assessed with myocardial strain of the 4-cardiac chambers according to the presence of clonal haematopoiesis (CH). Methods We retrospectively analysed 94 patients hospitalized for AF. All patients had clinical, biologic evaluation with dedicated analysis of CH, defined by the presence of mutation of variant allele frequency, VAF 1%. Using echocardiography and speckle tracking, we performed four-cardiac chambers strain analysis (left ventricle (LV), right ventricle (RV), left atrium (LA), right atrium (RA)) were analysed off-line using Ultrasound Workspace software, Philips (Figure 1). Patients were divided into two groups according to the presence (CH +, n=45) or absence (CH -, n=49) of clonality. Results Median age of the population was 69 (63-76) years, and 52 (55%) patients were male. CH+ patients, in comparison with CH - patients, had more frequently persistent AF (32(84%) versus 29(64%), p=0.049), and more frequently history of coronary artery stenting (4(8.9%) versus 0(0%). No significant differences were observed between CH + and CH – patients, concerning the history of hypertension (21(47%) versus 26(53%), p=0.54), diabetes (5(11%) versus 7(14%), p=0.64), and tobacco (22(49%) versus 20(41%), p=0.43). We found no significant differences in 2D TTE measurements and in global longitudinal LV, LA, RA and RV strains, between CH + and CH -. Conclusions In this preliminary work, clonal hematopoiesis of indeterminate potential (CHIP) did not seem to induce cardiac remodeling in AF. Further investigations are warranted in larger clinical studies and cohorts to evaluate the determinants of cardiac remodeling in AF patients and its possible implication.
Cohen et al. (Sat,) reported a other. Clonal hematopoiesis of indeterminate potential (CHIP) showed no significant impact on cardiac remodeling or myocardial strain in atrial fibrillation patients.