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Hydrogel-based drug delivery systems for enhanced tumor therapy | Synapse

February 8, 2026Open Access

Hydrogel-based drug delivery systems for enhanced tumor therapy

STShijia TianZunyi Medical University SYShuxiang YangZunyi Medical University YLYue LiuQingdao University

Key Points

This review aims to explore how hydrogel-based platforms can improve localized cancer therapy and counter drug resistance.
Review of existing literature on hydrogel drug delivery systems
Analysis of how these systems affect tumor microenvironment
Discussion of multiple treatment modalities utilizing hydrogels
Hydrogel systems provide spatiotemporal control for drug release
Enhanced therapeutic efficacy observed with reduced systemic toxicity
Modulation of tumor microenvironment aids in overcoming drug resistance

Abstract

This review highlights hydrogel-based platforms for spatiotemporally controlled, localized cancer therapy, overcoming drug resistance and modulating the tumor microenvironment to enhance efficacy and reduce toxicity for multiple treatment modalities.

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Cite This Study

Tian et al. (Thu,) studied this question.

synapsesocial.com/papers/698828620fc35cd7a8847dd0 https://doi.org/https://doi.org/10.1039/d5ra08269b