The efficacy and safety of high-frequency SMA-rTMS on freezing of gait in patients with Parkinson’s disease: a study protocol for a randomized controlled trial | Synapse
February 8, 2026Open Access
The efficacy and safety of high-frequency SMA-rTMS on freezing of gait in patients with Parkinson’s disease: a study protocol for a randomized controlled trial
Key Points
The research aims to evaluate the efficacy and safety of high-frequency SMA-rTMS in alleviating freezing of gait in patients with Parkinson's disease.
Conduct a randomized controlled trial registered with standard ethical approvals.
Target patients diagnosed with Parkinson's disease experiencing freezing of gait.
Implement high-frequency SMA-rTMS as the primary intervention.
Compare outcomes against a control group receiving a placebo.
Anticipated positive effects on reducing freezing of gait episodes.
Improvement in overall gait performance expected.
Safety and side effects of the intervention will be closely monitored.
Abstract
This trial has been registered in China Clinical Trials Registry (registration number: ChiCTR2100049370). (Registered on August 1, 2021).