Exercise-induced PVCs were linked to higher LV mass index (80.12 vs 74.27 g/m²), reduced GLS (-19.58% vs -22.22%), and elevated MPI (0.42 vs 0.38), indicating subclinical myocardial damage.
Are exercise-induced premature ventricular complexes associated with subclinical myocardial damage in asymptomatic individuals without structural heart disease?
In asymptomatic individuals without structural heart disease, exercise-induced premature ventricular complexes are associated with subclinical myocardial dysfunction, including impaired global longitudinal strain and increased left ventricular mass.
Absolute Event Rate: 0% vs 0%
Abstract Objective Exercise-induced premature ventricular complexes (EI-PVCs) are key indicators of subclinical cardiac dysfunction and elevated cardiovascular risk. However, their clinical significance and prognostic value remain unclear, particularly in asymptomatic individuals without structural heart disease. This study investigates the relationship between EI-PVCs and subclinical myocardial damage using advanced echocardiographic techniques. Methods An observational case-control study including 111 participants (52 controls and 59 cases) was conducted. Two-dimensional speckle tracking echocardiography (2D-STE) was utilized to assess myocardial function, including global longitudinal strain (GLS). Comprehensive clinical evaluations, treadmill exercise stress testing, and conventional echocardiography were performed to investigate cardiac structure and function. Results EI-PVCs were significantly associated with structural remodeling and impaired myocardial function. Specifically, the left ventricular mass index (LVMI) was significantly higher in the case group (80.12 ± 15.69 g/m²) compared to the control group (74.27 ± 12.70 g/m², p = 0.035). Global longitudinal strain (GLS), an advanced marker of myocardial contractility, was markedly reduced in the case group (-19.58 ± 2.00%) compared to the control group (-22.22 ± 1.38%, p 0.001). Moreover, the myocardial performance index (MPI) was elevated in the case group (0.42 ± 0.07) compared to controls (0.38 ± 0.06, p = 0.002), indicating impaired global ventricular function. Conclusion This study highlights EI-PVCs as early markers of subclinical myocardial dysfunction, warranting detailed echocardiographic evaluation in affected individuals. The findings underscore the need for further research into the burden, morphology, and patterns of EI-PVCs to refine cardiovascular risk stratification and management strategies.
Geneş et al. (Sat,) reported a other. Exercise-induced PVCs were linked to higher LV mass index (80.12 vs 74.27 g/m²), reduced GLS (-19.58% vs -22.22%), and elevated MPI (0.42 vs 0.38), indicating subclinical myocardial damage.