What question did this study set out to answer?

To investigate the relationship between time-updated body mass index (BMI) and the initiation of kidney replacement therapy (KRT) in patients with chronic kidney disease (CKD).

February 8, 2026Kidney Research and Clinical Practice0 citationsOpen Access

Association of time-updated body mass index with initiation of kidney replacement therapy in patients with chronic kidney disease: results from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) study

MKMinsang KimSeoul National University JKJ W KimSeoul National University YKYunmi KimInje University Busan Paik Hospital

Key Points

To investigate the relationship between time-updated body mass index (BMI) and the initiation of kidney replacement therapy (KRT) in patients with chronic kidney disease (CKD).
Analyzed data from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) study.
Examined obesity levels and their impact on KRT initiation.
Conducted statistical analysis to evaluate risk associations.
Higher time-updated BMI is associated with a lower risk of KRT initiation in obese patients.
Aggressive weight reduction may not provide benefits for those with both obesity and CKD.
Findings indicate the potential reevaluation of weight loss strategies in CKD management.

Abstract

A higher time-updated BMI has a lower risk of KRT initiation in obese patients with NDD-CKD. Therefore, aggressive reduction of body weight in patients with both obesity and CKD may not always be beneficial for adverse kidney events.

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Cite This Study

Kim et al. (Fri,) studied this question.

synapsesocial.com/papers/6988290a0fc35cd7a8849189 https://doi.org/https://doi.org/10.23876/j.krcp.25.237

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