MAPCAs were frequent across PH groups, notably 74.3% in group 4 and 70.5% in group 1, correlating with pulmonary hemodynamic severity and clinical risk.
Does the presence and severity of major aorto-pulmonary collateral arteries (MAPCAs) correlate with hemodynamic severity, risk status, and clinical outcomes across different pulmonary hypertension groups?
Major aorto-pulmonary collateral arteries are frequently recruited across multiple pulmonary hypertension groups (not just group 4) and are significantly associated with worse hemodynamic severity and clinical risk status.
Absolute Event Rate: 0% vs 0%
Abstract Background 0.001). In group 1 PH, moderate to severe MAPCA recruitment was observed in 31.4% of patients with idiopathic pulmonary arterial hypertension (IPAH), 29.4% with PAH associated with connective tissue diseases, and 28.9% with PAH associated with congenital heart disease (p 0.05). MAPCA grade was significantly associated with pulse oximetric saturation (%) (p = 0.03), brain natriuretic peptide (BNP) levels (p = 0.04), pulmonary arterial systolic and diastolic pressures (PASP, PAMP) estimated by Doppler echocardiography, invasively measured PASP and PAMP, right atrial mean pressure, pulmonary vascular resistance, and the pulmonary-to-systemic vascular resistance ratio (p 0.001 for all). All MRS models demonstrated significant associations between risk status and MAPCA grades (p = 0.015 to 0.001). Moreover, higher MAPCA grades were associated with clinical deterioration requiring IV diuretics, add-on triple therapy, and parenteral prostacyclins (p 0.05 for all), but not with overall survival (p 0.05). Conclusions Our results highlight the frequency of MAPCA recruitment across different PH groups and PAH subgroups, beyond group 4 PH. These collaterals appear to be associated with pulmonary hemodynamic severity and multiparametric clinical risk status in PH patients. However, the clinical significance of MAPCAs remains to be determined.
Kaymaz et al. (Sat,) reported a other. MAPCAs were frequent across PH groups, notably 74.3% in group 4 and 70.5% in group 1, correlating with pulmonary hemodynamic severity and clinical risk.