Association of mitochondrial oxidative capacity with physical fitness in ageing: the Baltimore longitudinal study of ageing.

Key Points

• To investigate the relationship between mitochondrial oxidative capacity and physical fitness in ageing individuals.
• Longitudinal study design based on the Baltimore Longitudinal Study of Ageing.
• Assessment of mitochondrial oxidative phosphorylation capabilities.
• Evaluation of cardiorespiratory fitness among participants.
• Higher mitochondrial oxidative capacity is associated with better cardiorespiratory fitness.
• The relationship is particularly notable in young and middle-aged adults.
• Interindividual variability in fitness levels is influenced by mitochondrial function.