“Side versus adverse effects of elexacaftor/tezacaftor/ivacaftor therapy in people with CF”

Key Points

• This study aims to differentiate between side effects and adverse effects of elexacaftor/tezacaftor/ivacaftor therapy in cystic fibrosis (CF).
• Analyzed real-world efficacy of elexacaftor/tezacaftor/ivacaftor therapy in adults with CF.
• Evaluated the nature and duration of side effects and adverse effects of the therapy.
• Side effects from CFTR restoration are mostly self-limiting.
• Adverse effects due to drug toxicity are more persistent and often lead to therapy discontinuation.