Inadequate ovarian function suppression and endocrine therapy manipulations in premenopausal patients with early breast cancer on adjuvant LHRH agonist and aromatase inhibitor: a cohort study

Key Points

• To investigate the occurrence and management of inadequate ovarian function suppression during LHRH agonist therapy in early breast cancer.
• Cohort study design focusing on premenopausal patients with early breast cancer
• Patients received LHRH agonist therapy in combination with aromatase inhibitors
• Continuous monitoring of estradiol levels during treatment to manage endocrine therapy adjustments
• Inadequate ovarian function suppression was found to be transient and potentially recurring
• Continuous estrogen monitoring throughout therapy was deemed essential
• Timely implementation of endocrine therapy manipulations was supported by the findings