What question did this study set out to answer?

To evaluate the effects of BCG vaccination on the immune system and responses to influenza vaccination in elderly individuals.

February 9, 2026Vaccine0 citationsOpen Access

Evaluating the non-specific effects of BCG vaccination on the immune system and serological response to influenza vaccination in the elderly: A randomised controlled trial

AMAnne Marie Rosendahl Madsen FSFrederik Schaltz‐Buchholzer RTRamona Trebbien

Key Points

To evaluate the effects of BCG vaccination on the immune system and responses to influenza vaccination in elderly individuals.
Randomised controlled trial
Participants included Danish senior citizens
Compared BCG vaccination to placebo
Measured serological responses to influenza vaccination
BCG vaccination did not affect serological response to influenza
No reduction in the risk of influenza infection compared to placebo
No evidence of trained immunity induction observed

Abstract

In this randomised clinical trial of Danish senior citizens, BCG vaccination did not influence serological response to influenza vaccination or reduce the risk of infection compared with placebo. There was no clear indication of induction of trained immunity.

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Cite This Study

Madsen et al. (Thu,) studied this question.

synapsesocial.com/papers/69897983f0ec2af6756e7374 https://doi.org/https://doi.org/10.1016/j.vaccine.2026.128305

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