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Metabolic biomarkers add little to diagnostic performance of FIB-4 in MASLD. | Synapse

February 9, 20260 citations

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Metabolic biomarkers add little to diagnostic performance of FIB-4 in MASLD.

SUSofia Ullman HHHannes Hegmar JVJohan Vessby

Key Points

This research investigates the impact of adding metabolic biomarkers to FIB-4 for diagnosing advanced fibrosis.
Evaluated diagnostic performance of FIB-4 alone and with added biomarkers (CRP, HbA1c, HOMA-IR, uric acid).
Assessed statistical significance of diagnostic improvement with combined markers.
No statistically significant improvement in diagnostic performance when adding biomarkers to FIB-4.
The additional biomarkers (CRP, HbA1c, HOMA-IR, uric acid) provided limited value in identifying advanced fibrosis.

Abstract

Adding CRP, HbA1c, HOMA-IR, or uric acid to FIB-4 did not result in any statistically significant improvement in diagnostic performance, suggesting limited additional value of these biomarkers in identifying advanced fibrosis.

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Cite This Study

Ullman et al. (Fri,) studied this question.

synapsesocial.com/papers/69897a06f0ec2af6756e82ba https://doi.org/https://doi.org/10.1080/00365521.2026.2615408