Progranulin impairs efferocytosis of macrophages in renal fibrosis by negatively regulating PPAR-δ-mediated inhibition of the JAK-STAT signaling pathway | Synapse
February 9, 2026Cellular and Molecular Life Sciences0 citationsOpen Access
Progranulin impairs efferocytosis of macrophages in renal fibrosis by negatively regulating PPAR-δ-mediated inhibition of the JAK-STAT signaling pathway
The study aims to investigate the role of progranulin in impairing macrophage efferocytosis during renal fibrosis.
Examined the interaction between progranulin and PPAR-δ.
Analyzed the effects on STAT1/2 signaling in macrophages.
Evaluated macrophage clearance of apoptotic cells in renal fibrosis contexts.
Progranulin binding to PPAR-δ was confirmed.
Activation of the STAT1/2 signaling pathway was observed.
Impaired clearance of apoptotic cells due to inhibited macrophage efferocytosis was demonstrated.
Abstract
PGRN inhibits macrophage efferocytosis during renal fibrosis by binding and inhibiting PPAR-δ, thereby activating the STAT1/2 signaling pathway and impairing the clearance of apoptotic cells.