Electrophysiologic Characteristics of Epidural Spinal Signals in Preclinical Models of Spinal Cord Stimulation

Key Points

• The aim is to investigate the electrophysiologic characteristics of spinal signals in response to spinal cord stimulation.
• Analyzed waveform and recruitment thresholds of signals evoked by spinal cord stimulation.
• Assessed potential physiologic origins of these signals.
• Evaluated signals as biomarkers of nociceptive pathway dysregulation.
• Identified distinct waveform characteristics of spinal signals.
• Signals demonstrated varying recruitment thresholds based on the stimulation.
• Proposed that signals correlate with the efficacy and side effects of spinal cord stimulation.