Abstract Purpose of Review Schema therapy is an evidence-based treatment for personality disorders (PDs), with ‘schema modes’ being a core theoretical and clinical concept. Despite their centrality, empirical research into the mechanisms of schema mode activation remains limited. This paper reviews the available research on schema mode activation and provides methodological guidelines and a research agenda to stimulate experimental research on schema modes. Recent Findings We identified five published studies that experimentally induced schema modes using a variety of procedures (e.g., stress interviews, film clips, and art/drama therapy), showing diverse but generally significant effects on mode activation. Their findings underscore the need for validated and replicable experimental paradigms, as effects were highly dependent on sample characteristics, procedure-specific variability, and discrepancies between therapist- and patient ratings of schema mode activation. Building on insights from emotion induction research, we propose two procedures for experimental schema mode induction: guided autobiographical recall/scripted imagery and stimulus-based experimental triggers. We outline best practices, challenges, and recommendations for designing and validating such procedures. A future research agenda is presented, focusing on identifying conditions that activate schema modes and examining their effects on information processing and behavior. Summary By developing validated experimental tools and adopting open science practices, we aim to stimulate further experimental research to empirically test schema therapy’s theoretical premises and clarify the role of schema modes in PDs.
Krans et al. (Mon,) studied this question.