What question did this study set out to answer?

To report a rare case of severe palpitations and drug-resistant sinus tachycardia associated with high-dose spironolactone therapy.

February 11, 2026Clinical Case Reports0 citationsOpen Access

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Drug‐Resistant Sinus Tachycardia as a Dose‐Dependent Side Effect of Spironolactone: A Case Report and Review of the Literature

ZAZahra Abdi MCMaryam Chenaghlou ARAysa rezabakhsh

Key Points

To report a rare case of severe palpitations and drug-resistant sinus tachycardia associated with high-dose spironolactone therapy.
Analyzed a case of a normotensive patient experiencing severe palpitations
Reviewed existing literature on spironolactone side effects
Monitored cardiac responses during treatment
Identified drug-resistant sinus tachycardia as a side effect of high-dose therapy
Emphasized the necessity for careful titration of spironolactone
Highlighted the importance of cardiac monitoring in patients receiving spironolactone

Abstract

ABSTRACT Spironolactone is widely used for polycystic ovarian syndrome due to its anti‐androgenic properties. However, rare cardiovascular side effects may occur even in normotensive patients. We report a case of severe palpitations and drug‐resistant sinus tachycardia following high‐dose therapy, emphasizing the need for cautious titration and cardiac monitoring.

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Cite This Study

Abdi et al. (Sun,) studied this question.

synapsesocial.com/papers/698c1bdc267fb587c655dd65 https://doi.org/https://doi.org/10.1002/ccr3.71875

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