An Altered Ratio of CD4+ and CD8+ T Lymphocytes in Cervical Cancer Tissue and Peripheral Blood as a Predictor of Prognostic Outcome: A Clinicopathological Study

Key Points

• The aim is to explore the differences in CD4+ and CD8+ T lymphocyte ratios between cervical cancer tissues and peripheral blood and their prognostic implications.
• Analyzed T lymphocyte populations in tumor tissue and peripheral blood.
• Compared levels of CD4+ and CD8+ T lymphocytes in locally advanced cervical cancer cases.
• Evaluated associations between T lymphocyte subpopulations and prognostic factors.
• CD4+ and CD8+ T lymphocyte levels are significantly lower in tumor tissue than in peripheral blood.
• No correlation found between T lymphocyte subpopulations and major prognostic factors in cervical cancer.
• Enhanced TILs in HPV-associated cases indicate potential for new treatment strategies.