Effect of Mitophagy on the Tension-Driven Osteogenic Differentiation of Periodontal Ligament Stem Cells During Ageing

Key Points

• The research aims to explore how mitophagy affects the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) under tension during ageing.
• Examined the role of mitophagy in PDLSCs under tension conditions.
• Analyzed osteogenic differentiation markers in PDLSCs.
• Investigated age-related differences in mitophagy activity in PDLSCs.
• Mitophagy enhances osteogenic differentiation in PDLSCs when subjected to tension.
• Age affects the efficiency of mitophagy in PDLSCs, suggesting changes in differentiation ability over time.