Purpose of review Post-traumatic care is evolving from a reactive, protocol-driven paradigm to a predictive, personalized approach. This review examines how artificial intelligence and machine learning are redefining postoperative management by predicting complications before they manifest. Recent findings Recent literature (2023–2025) highlights three major advances: (a) the validation of gradient boosting algorithms (e.g. Extreme Gradient Boosting) that significantly outperform traditional scoring systems for predicting trauma-induced coagulopathy; (b) the development of interpretable, phenotype-specific models for venous thromboembolism risk stratification, particularly in traumatic brain injury; and (c) the emergence of real-time sepsis prediction tools that account for the sterile inflammation inherent to trauma. However, a recurring limitation in current research is the reliance on retrospective datasets and single-center validations, underscoring the critical need for rigorous external validation across diverse patient populations before widespread clinical adoption. Summary Artificial intelligence is not merely a monitoring tool but a driver of precision medicine in trauma. By leveraging diverse modalities, from computer vision in radiology to natural language processing in electronic health records, clinicians can now anticipate adverse events. To bridge the gap between algorithm and bedside, future efforts must focus on overcoming significant implementation barriers, such as data interoperability, and ensuring model generalizability.
Duranteau et al. (Mon,) studied this question.