TMEPAI Confers Paclitaxel Resistance in Triple-Negative Breast Cancer Cells by Promoting AKT Phosphorylation and Its Downstream Cascade

Key Points

• The study aims to investigate how TMEPAI influences paclitaxel resistance in triple-negative breast cancer cells.
• In vitro experiments conducted on triple-negative breast cancer cell lines
• Assessment of TMEPAI levels in relation to paclitaxel response
• Measurement of AKT phosphorylation and apoptosis rates
• TMEPAI levels correlate with increased paclitaxel resistance
• Enhanced AKT phosphorylation observed in resistant cells
• Reduction in apoptosis and increased drug efflux noted in cells with higher TMEPAI levels