Distinct epigenetic aging in sporadic and hereditary neuroendocrine neoplasms

Key Points

• This research aims to compare epigenetic aging patterns in sporadic and hereditary neuroendocrine neoplasms (NEN).
• Conducted epigenetic age analysis
• Performed age acceleration analysis
• Compared findings between sporadic and hereditary NEN
• Sporadic NEN exhibited higher epigenetic age and acceleration
• Hereditary NEN showed reduced epigenetic alteration impact
• Distinct patterns indicate different pathogenesis mechanisms