Abstract A preparative method has been developed for the synthesis of 1,3,5-trinitro-2-(prop-2-yn-1-yloxy)benzene in 79% yield under mild conditions from commercially available initial compounds. The structure of the title compound has been confirmed by 1 H NMR spectroscopy. 1,3,5-Trinitro-2-(prop-2-yn-1-yloxy)benzene has been found to form noncovalent bioconjugates with DNA molecules and deoxynucleoside triphosphates. The resulting bioconjugates can be involved in click reactions with azide dyes.
Kazantsev et al. (Mon,) studied this question.