Investigation of the Anticancer Effects and Senescence Induction of Hesperetin Combined with Cisplatin in Hepatocellular Carcinoma and Embryonic Fibroblast Cell Lines

Key Points

• Evaluate the anticancer effects of hesperetin when combined with cisplatin in cancer and normal cell lines.
• Co-treatment of hepatocellular carcinoma and embryonic fibroblast cell lines with hesperetin and cisplatin.
• Assessment of cell viability and senescence induction.
• Co-treatment significantly reduces cancer cell viability.
• Normal fibroblasts are protected from senescence with the treatment.