Rh(III)-Catalyzed Enantioselective C–H Arylation: Atroposelective Synthesis of 2-Pyridones from Diazo Compounds

Key Points

• The aim is to develop an enantioselective C–H arylation method for synthesizing axially chiral 2-pyridones from diazo compounds.
• Implemented Rh(III) catalysis for the C–H arylation process.
• Utilized diazo compounds to facilitate the reaction.
• Focused on the C6 position of 2-pyridones in the synthesis.
• Successfully achieved enantioselectivity in the resulting 2-pyridones.
• Demonstrated the potential for creating diverse axially chiral structures.
• Showed compatibility with various substituted diazo compounds.