Synthesis of α-chloro-β-ketoesters via ytterbium(III) triflate-mediated decarboxylative Claisen-type condensation

Key Points

• To develop a reliable method for synthesizing α-chloro-β-ketoesters using Yb(OTf)3.
• Utilized ytterbium(III) triflate as a catalyst
• Employed decarboxylative Claisen-type condensation technique
• Conducted reactions under mild conditions
• Synthesis yielded products with a range of 78–95% efficiency
• Successfully avoided functional-group incompatibility issues
• Minimized side reactions during the process