What question did this study set out to answer?

This research aims to find metabolic gene signatures that can predict rejection of kidney transplants.

February 12, 2026Renal Failure0 citationsOpen Access

Immunometabolic transcriptomic signatures of diabetes-related genes predict kidney transplant rejection

RCRoberto Casale ASAndrea Dello Strologo CACarlo Alfieri

Key Points

This research aims to find metabolic gene signatures that can predict rejection of kidney transplants.
Identification of metabolic gene signatures
Analysis of gene expression related to diabetes
Assessment of metabolic pathways affecting graft rejection
Distinct downregulation of DPP4 observed
Upregulation of PPARG and INSR identified
Metabolic reprogramming linked to immune-mediated graft failure

Abstract

We identified a distinct metabolic gene signature capable of predicting kidney transplant rejection. The downregulation of DPP4 with the upregulation of PPARG and INSR suggests that metabolic reprogramming and loss of homeostasis are hallmarks of immune-mediated graft failure.

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Cite This Study

Casale et al. (Mon,) studied this question.

synapsesocial.com/papers/698d6dae5be6419ac0d52c00 https://doi.org/https://doi.org/10.1080/0886022x.2026.2626857

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