Posterior displacement of an aortic entrainment blood pump reduced the hemolysis index by 19.6% but increased the thrombosis index by 4.9% across the cardiac cycle in a computational model.
Does the implantation position of a novel entrainment blood pump affect aortic hemodynamics and renal perfusion in a computational model?
Computational modeling demonstrates that the implantation position of an aortic entrainment blood pump significantly impacts hemodynamics, renal perfusion, and risks of hemolysis and thrombosis.
Cardiorenal syndrome (CRS) exhibits high in-hospital mortality. Although aortic entrainment pumps can improve CRS patients' hemodynamics, they can carry risks of blood-related complications. The limitations are further exacerbated by existing numerical studies, which often neglect arterial compliance and transient cardiac effects. Therefore, this study employed computational fluid dynamics (CFD) combined with a three-element Windkessel model to investigate the impact of different implantation positions on the aortic hemodynamics. The results showed that the blood pump implanted in the middle location of the aorta yielded the maximum aortic pressure and significantly enhanced the perfusion of the renal arteries. The blood pump induced the peak levels of wall shear stress (WSS) and scalar shear stress (SSS) at the peak systole phase. Posterior displacement of the blood pump reduced the hemolysis index (HI) by 19.6%, yet it resulted in an average increase of 4.9% in the thrombosis index (TI) across the entire cardiac cycle. This study used dynamic boundary conditions and made the working environment of the blood pump in the aorta more realistic. Meanwhile, the optimal implantation position of the blood pump in clinical treatment has a positive effect on improving the treatment effect.
Lv et al. (Tue,) conducted a other in Cardiorenal syndrome (CRS). Aortic entrainment blood pump vs. Different implantation positions was evaluated on Aortic hemodynamics (aortic pressure, renal perfusion, hemolysis index, thrombosis index). Posterior displacement of an aortic entrainment blood pump reduced the hemolysis index by 19.6% but increased the thrombosis index by 4.9% across the cardiac cycle in a computational model.