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This study aims to evaluate the effectiveness of the basophil activation test (BAT) in diagnosing tocilizumab hypersensitivity.

February 12, 2026Clinical & Experimental Allergy0 citationsOpen Access

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Basophil Activation Test for the In Vitro Diagnosis of Tocilizumab Hypersensitivity

AKAna KorenUniversity Clinic of Pulmonary and Allergic Diseases Golnik LDLuka DejanovićUniversity Clinic of Pulmonary and Allergic Diseases Golnik PKPeter KorošecJožef Stefan Institute

Key Points

This study aims to evaluate the effectiveness of the basophil activation test (BAT) in diagnosing tocilizumab hypersensitivity.
Performed a basophil activation test to assess allergic reactions to tocilizumab.
Compared BAT results with skin tests and IgE measurements.
Analyzed the correlation between IgE-allergenic activity and hypersensitivity symptoms.
BAT successfully detected hypersensitivity reactions not identified by traditional methods.
Findings indicate BAT's superior sensitivity for diagnosing tocilizumab allergies.
Correlation found between BAT results and observed allergic symptoms.

Abstract

Summary Basophil activation test (BAT) is a useful approach for diagnosing hypersensitivity reactions to tocilizumab. BAT offers insight into IgE‐allergenic activity beyond sensitisation, complementing skin tests and IgE measurements.

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Basophil Activation Test for the In Vitro Diagnosis of Tocilizumab Hypersensitivity

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Abstract

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