What question did this study set out to answer?

This research aims to develop a ruthenium-catalyzed method for site-selective C-H allylation of aryl ketones.

February 12, 2026Chemical Communications0 citations

Ruthenium-catalyzed site-selective C-H allylation of aryl ketones using Morita-Baylis-Hillman alcohols: access to α-benzyl acrylates

HBHemanga Bhattacharyya SSSharajit Saha SKSrikrishna Khamrai

Key Points

This research aims to develop a ruthenium-catalyzed method for site-selective C-H allylation of aryl ketones.
Utilized ruthenium as a catalyst for C–H allylation
Applied Morita-Baylis-Hillman alcohols as reagents
Explored substrate scope and functional group tolerance
Successfully synthesized α-benzyl acrylates from aryl ketones
Demonstrated high selectivity in C-H bond activation
Showed effective late-stage diversification to substituted indanes

Abstract

Ru-catalyzed weak-chelation-assisted site-selctive C–H allylation of aryl ketones has been accomplished with MBH alcohols to furnish α-benzyl acrylates. Substrate scope, functional group tolerance, and late-stage diversification to substituted indanes and...

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