The Novel HLA ‐B*15:730 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual

Key Points

• To identify and characterize the novel HLA-B*15:730 allele in a specific individual.
• Utilized Sanger dideoxy nucleotide sequencing to determine genetic composition.
• Focused on the HLA-B locus, specifically exon 3.
• Discovered that HLA-B*15:730 differs from HLA-B*15:12:01 by a single nucleotide change.
• Identified a non-synonymous change that may affect protein function.